A. Problems of
plasmodium falciparium drugs resistant:
The malaria parasite has proved a formidable adversary for medical researchers.
It owes its success to the fact that it has chosen not to live as a free living
organism but a parasite. It has adapted to the host and host immune system
(Nowikowsks 1987). Resistance of P. falciparium
to drugs has become the most important threat to effective control of
the
disease. It has risen to a combination of massive drug and a failure to combat
transmission of the disease by Onori (1984).B. Side effect of anti-malarial: The toxicity and side effects of antimalarial drugs in Africa were reviewed by Salako(1984).He draws attention to pruritus adverse reactions associated with the genetic abnormality that plays a part in the incidence of reaction to primaquine and quinine. Apart from nausea, vomiting, headache, dizziness, blurring of vision, mental and physical weakness and fatigue which are usually mild, more adverse reactions including itching, cardiovascular abnormalities, neuromuscular disorders , ocular damage and hearing loss are also side effects of antimalaria drugs(Salako 1984). A mild itching without rash can occur following the administration of chloroquine in all races, more severe itching occurs in Africans.
C. Vector resistance
to insecticides: Resistance to insecticides has been defined as the ability of a
population of insects to tolerate doses of an insecticide that would prove
lethal to the majority of individuals in a normal population of the same
species. This biological phenomen on develops as a result of selection by the
relevant insecticidal compounds (Bruce-chwatt, 1983).
It is a known fact that insecticides
resistance is one of the major obstacles in the struggle against vector borne
diseases.
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