This reaction is an antibiotic side effect due to drug - drug interaction. Immunoglobulin E (IgE) medication hypersensitivity reactions are the most feared adverse effect attributed to the penicillins, imipenem and cilastatin and cephalosporins. These reactions are manifested by urticaria, pruritis, hypertension, bronchospasm, and laryngeal edema.
Of the note is the association between an increased risk and severity of an allergic drug reaction to penicillin when Beta-blockers are used concomitantly. Severe cutaneous reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, and small vessel vasculitis compose “late” or delayed hypersensitivity reactions. Classically, sulfonamides have been associated with these dermatologic reactions, but penicillins, cephalosporins, fluoroquinolones and vancomycin have been implicated as well.
Patients with cystic fibrosis have experienced allergic reactions, consisting of drug - induced fever and rash, when they receive a specific Beta-lactam antibiotics parenterally, namely piperacillum, mezlocillin and imipenem and cilastatin. The importance of this observation is that drug-induced fever can precede the development of more serious manifestations, such as hepatitis and exfoliative dermatitis
Of the note is the association between an increased risk and severity of an allergic drug reaction to penicillin when Beta-blockers are used concomitantly. Severe cutaneous reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, and small vessel vasculitis compose “late” or delayed hypersensitivity reactions. Classically, sulfonamides have been associated with these dermatologic reactions, but penicillins, cephalosporins, fluoroquinolones and vancomycin have been implicated as well.
Patients with cystic fibrosis have experienced allergic reactions, consisting of drug - induced fever and rash, when they receive a specific Beta-lactam antibiotics parenterally, namely piperacillum, mezlocillin and imipenem and cilastatin. The importance of this observation is that drug-induced fever can precede the development of more serious manifestations, such as hepatitis and exfoliative dermatitis