Trimothoprian, a potent inhibitor of bacterial dihydrofolate redctases, exhibits an anti-baterial spectrum similar to the sulfornamides. Hoever, trimetthroprim is most often compounded with sulfamethoxazole and used for the treatment of urinary tracts infections due to susceptible strains of E.Coli, P. mirabilis, K.pneumorniae, Enterobacter specie and coagulase-negative staphylococcus.
Adverse Effect
Gastrointestinal effects – The most common adverse effects associated with trimethoprin as gastronterestinal. They include loss of appetite, nausea, vomiting, diarrhea, abdominal pain, abnormal taste and swelling of the tongue.
Anemia – Trimethroprim may cause anemia due to a deficiency of folic acid. The anemia usually is mild and resolves when the trimetroprin is stopped. Patients who are folate-deficient, such as malnourished, alcoholic, geriatric or pregnant patients, may be at greater risk for developing anemia with trimethoprim.
Photosensistivity reactions- Patients develop skin rashes and itching on parts of their body that are exposed to the sun.
Adverse Effect
Gastrointestinal effects – The most common adverse effects associated with trimethoprin as gastronterestinal. They include loss of appetite, nausea, vomiting, diarrhea, abdominal pain, abnormal taste and swelling of the tongue.
Anemia – Trimethroprim may cause anemia due to a deficiency of folic acid. The anemia usually is mild and resolves when the trimetroprin is stopped. Patients who are folate-deficient, such as malnourished, alcoholic, geriatric or pregnant patients, may be at greater risk for developing anemia with trimethoprim.
Photosensistivity reactions- Patients develop skin rashes and itching on parts of their body that are exposed to the sun.