ADVERSE EFFECTS OF CEPHALOSPORINS - ANTIBIOTICS

Cephalosoprins are a class of β-laetam antibiotics originally derived from Acremonium, which is previously known as cephalosporium. Together with cephamycins they contribute a sub-ground of β-laetam antibiotics called cephems. Like the penicilins, cephalosporins have beta-lactam ring structure that interferes with synthesis of the bacterial cell wall and so are bactericidal (which means that they kill bacteria).

Adverse Effect

Digestive system- Mild stomach cramps or upset, nausea, vomiting and diarrhoea. These side effects are usually mild and go away over time.

Organism overgrowth – cephalosporins can sometimes cause overgrowth of fungus normally present in the body system. This overgrowth can cause wild side effects such as a sore tongue, sores inside the mouth, or vaginal yeast infections.

Allergic manifestations – Because the cephalosporins are structurally similar to the penicilins, some patients allergic to penicillins, some patients allergic to penicillins may be allergic to a cephalosporing antibiotic. The incidence of cross-sensitivity is approximately 5-10%.

Other Effects- more serious but infrequent reactions that can sometimes occur with cephalosporins include: black, tarry stools, chest pain, fever, painful or difficult urination, allergic reactions, serious colitis. Serious colitis is a rare side effect that includes severe water diarrhea (sometimes containing blood or mucus), severe stomach cramps, fever and weakness or faintness.
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